Assay Detail
Functional
CHEMBL886104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at LXRalpha LBD by HTRF cofactor peptide recruitment assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.26 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 7.40 |
| CHEMBL59030 | — | — | 1 | 6.43 |
| CHEMBL251538 | — | — | 1 | 6.27 |
| CHEMBL251331 | — | — | 1 | 6.24 |
| CHEMBL233369 | — | — | 1 | 5.82 |
| CHEMBL398680 | — | — | 1 | 5.37 |
| CHEMBL400937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL59030 | — | EC50 | = | 367.0 | nM | 6.43 |
| CHEMBL251538 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL251331 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL233369 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL398680 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL400937 | — | EC50 | > | 30000.0 | nM | - |