Assay Detail
Functional
CHEMBL886106
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of LXRbeta co-transfected in COS7 cells with RXRalpha by reporter transactivation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.15 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 7.96 |
| CHEMBL59030 | — | — | 1 | 7.82 |
| CHEMBL251331 | — | — | 1 | 7.28 |
| CHEMBL233369 | — | — | 1 | 7.19 |
| CHEMBL398680 | — | — | 1 | 6.92 |
| CHEMBL400937 | — | — | 1 | 6.47 |
| CHEMBL251538 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL59030 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL251331 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL233369 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL398680 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL400937 | — | EC50 | = | 336.0 | nM | 6.47 |
| CHEMBL251538 | — | EC50 | = | 363.0 | nM | 6.44 |