Assay Detail
Functional
CHEMBL886226
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Cytotoxicity against human HeLa cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of naphthalene analogues of phenstatins: naphthylphenstatins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.73 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL85065 | NAPHTHYLCOMBRETASTATIN | — | 1 | 7.70 |
| CHEMBL410946 | — | — | 1 | 7.38 |
| CHEMBL247386 | — | — | 1 | 5.77 |
| CHEMBL247387 | — | — | 1 | 5.57 |
| CHEMBL245767 | — | — | 1 | 5.42 |
| CHEMBL247187 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL85065 | NAPHTHYLCOMBRETASTATIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL410946 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL247386 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL247387 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL245767 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL247187 | — | IC50 | > | 10000.0 | nM | - |