Assay Detail
Binding
CHEMBL886231
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Inhibition of VZV DNA polymerase by scintillation proximity assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.44 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248363 | — | — | 1 | 7.72 |
| CHEMBL248161 | — | — | 1 | 7.68 |
| CHEMBL245899 | — | — | 1 | 6.70 |
| CHEMBL29711 | APHIDICOLIN | — | 1 | 6.33 |
| CHEMBL247130 | — | — | 1 | 6.11 |
| CHEMBL245900 | — | — | 1 | 5.30 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 5.24 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248363 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL248161 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL245899 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL247130 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL245900 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL666 | FOSCARNET | IC50 | - | — | - |