Assay Detail
Functional
CHEMBL886413
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Antagonist activity at GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as reduction of GABA-induced chloride ion currents
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Phosphonic acid analogs of GABA through reductive dealkylation of phosphonic diesters with lithium trialkylborohydrides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.10 | 6.17 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397209 | — | — | 1 | 6.17 |
| CHEMBL393506 | — | — | 1 | 4.96 |
| CHEMBL247531 | — | — | 1 | 4.17 |
| CHEMBL246068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397209 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL393506 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL247531 | — | IC50 | = | 68200.0 | nM | 4.17 |
| CHEMBL246068 | — | Activity | - | — | - |