Assay Detail
Binding
CHEMBL886419
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Magnaporthe grisea Guy 11 isocitrate lyase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pyricularia grisea |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Isocitrate lyase (CHEMBL1075264) ↗| Type | SINGLE PROTEIN |
| Organism | Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae) |
Publication
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.48 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387584 | HALISULFATE 1 | — | 1 | 4.90 |
| CHEMBL230058 | HYDROHALISULFATE 1 | — | 1 | 4.82 |
| CHEMBL230057 | HALISULFATE 5 | — | 1 | 4.17 |
| CHEMBL231421 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387584 | HALISULFATE 1 | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL230058 | HYDROHALISULFATE 1 | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL230057 | HALISULFATE 5 | IC50 | = | 67400.0 | nM | 4.17 |
| CHEMBL231421 | — | IC50 | = | 92400.0 | nM | 4.03 |