Assay Detail
Binding
CHEMBL886439
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Inhibition of human ERbeta
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.40 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.49 |
| CHEMBL250097 | — | — | 1 | 7.25 |
| CHEMBL402491 | — | — | 1 | 7.06 |
| CHEMBL402492 | — | — | 1 | 7.01 |
| CHEMBL198411 | — | — | 1 | 6.67 |
| CHEMBL372783 | — | — | 1 | 6.67 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 6.40 |
| CHEMBL197667 | — | — | 1 | 6.34 |
| CHEMBL198089 | — | — | 1 | 6.30 |
| CHEMBL250302 | — | — | 1 | 6.30 |
| CHEMBL250300 | — | — | 1 | 6.28 |
| CHEMBL250507 | — | — | 1 | 6.26 |
| CHEMBL250301 | — | — | 1 | 6.21 |
| CHEMBL198679 | — | — | 1 | 6.20 |
| CHEMBL402493 | — | — | 1 | 6.19 |
| CHEMBL398815 | — | — | 1 | 6.09 |
| CHEMBL437390 | — | — | 1 | 5.99 |
| CHEMBL398814 | — | — | 1 | 5.95 |
| CHEMBL440757 | — | — | 1 | 5.82 |
| CHEMBL250505 | — | — | 1 | 5.63 |
| CHEMBL250506 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL250097 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL402491 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL402492 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL198411 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL372783 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL44 | GENISTEIN | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL197667 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL198089 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL250302 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL250300 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL250507 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL250301 | — | IC50 | = | 624.0 | nM | 6.21 |
| CHEMBL198679 | — | IC50 | = | 634.0 | nM | 6.20 |
| CHEMBL402493 | — | IC50 | = | 641.0 | nM | 6.19 |
| CHEMBL398815 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL437390 | — | IC50 | = | 1017.0 | nM | 5.99 |
| CHEMBL398814 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL440757 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL250505 | — | IC50 | = | 2345.0 | nM | 5.63 |
| CHEMBL250506 | — | IC50 | = | 5235.0 | nM | 5.28 |