Assay Detail
Functional
CHEMBL886454
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human recombinant P2X7 receptor
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.62 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393241 | — | — | 1 | 7.72 |
| CHEMBL396587 | — | — | 1 | 7.57 |
| CHEMBL208560 | — | — | 1 | 7.40 |
| CHEMBL247586 | — | — | 1 | 7.32 |
| CHEMBL245561 | — | — | 1 | 7.31 |
| CHEMBL247782 | — | — | 1 | 7.31 |
| CHEMBL246578 | — | — | 1 | 7.30 |
| CHEMBL245758 | — | — | 1 | 7.23 |
| CHEMBL441479 | — | — | 1 | 7.19 |
| CHEMBL245754 | — | — | 1 | 7.11 |
| CHEMBL245560 | — | — | 1 | 6.93 |
| CHEMBL245972 | — | — | 1 | 6.88 |
| CHEMBL245756 | — | — | 1 | 6.88 |
| CHEMBL246172 | — | — | 1 | 6.86 |
| CHEMBL245562 | — | — | 1 | 6.84 |
| CHEMBL245973 | — | — | 1 | 6.72 |
| CHEMBL245755 | — | — | 1 | 6.72 |
| CHEMBL246770 | — | — | 1 | 6.68 |
| CHEMBL245578 | — | — | 1 | 6.67 |
| CHEMBL392216 | — | — | 1 | 6.52 |
| CHEMBL392171 | — | — | 1 | 6.48 |
| CHEMBL393485 | — | — | 1 | 6.37 |
| CHEMBL265896 | — | — | 1 | 6.28 |
| CHEMBL246767 | — | — | 1 | 6.22 |
| CHEMBL391960 | — | — | 1 | 6.04 |
| CHEMBL246173 | — | — | 1 | 5.98 |
| CHEMBL392170 | — | — | 1 | 5.89 |
| CHEMBL429110 | — | — | 1 | 5.74 |
| CHEMBL393684 | — | — | 1 | 5.22 |
| CHEMBL245775 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393241 | — | IC50 | = | 19.05 | nM | 7.72 |
| CHEMBL396587 | — | IC50 | = | 26.92 | nM | 7.57 |
| CHEMBL208560 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL247586 | — | IC50 | = | 47.86 | nM | 7.32 |
| CHEMBL245561 | — | IC50 | = | 48.98 | nM | 7.31 |
| CHEMBL247782 | — | IC50 | = | 48.98 | nM | 7.31 |
| CHEMBL246578 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL245758 | — | IC50 | = | 58.88 | nM | 7.23 |
| CHEMBL441479 | — | IC50 | = | 64.57 | nM | 7.19 |
| CHEMBL245754 | — | IC50 | = | 77.62 | nM | 7.11 |
| CHEMBL245560 | — | IC50 | = | 117.49 | nM | 6.93 |
| CHEMBL245972 | — | IC50 | = | 131.83 | nM | 6.88 |
| CHEMBL245756 | — | IC50 | = | 131.83 | nM | 6.88 |
| CHEMBL246172 | — | IC50 | = | 138.04 | nM | 6.86 |
| CHEMBL245562 | — | IC50 | = | 144.54 | nM | 6.84 |
| CHEMBL245973 | — | IC50 | = | 190.55 | nM | 6.72 |
| CHEMBL245755 | — | IC50 | = | 190.55 | nM | 6.72 |
| CHEMBL246770 | — | IC50 | = | 208.93 | nM | 6.68 |
| CHEMBL245578 | — | IC50 | = | 213.8 | nM | 6.67 |
| CHEMBL392216 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL392171 | — | IC50 | = | 331.13 | nM | 6.48 |
| CHEMBL393485 | — | IC50 | = | 426.58 | nM | 6.37 |
| CHEMBL265896 | — | IC50 | = | 524.81 | nM | 6.28 |
| CHEMBL246767 | — | IC50 | = | 602.56 | nM | 6.22 |
| CHEMBL391960 | — | IC50 | = | 912.01 | nM | 6.04 |
| CHEMBL246173 | — | IC50 | = | 1047.13 | nM | 5.98 |
| CHEMBL392170 | — | IC50 | = | 1288.25 | nM | 5.89 |
| CHEMBL429110 | — | IC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL393684 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL245775 | — | IC50 | = | 8912.51 | nM | 5.05 |
| CHEMBL246375 | — | IC50 | = | 13182.57 | nM | 4.88 |