Assay Detail
Binding
CHEMBL886472
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Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 8.53 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398034 | — | — | 1 | 10.20 |
| CHEMBL394690 | — | — | 1 | 9.80 |
| CHEMBL246918 | — | — | 1 | 9.50 |
| CHEMBL246706 | — | — | 1 | 9.40 |
| CHEMBL246705 | — | — | 1 | 9.40 |
| CHEMBL246499 | — | — | 1 | 9.40 |
| CHEMBL246291 | — | — | 1 | 9.30 |
| CHEMBL246704 | — | — | 1 | 9.20 |
| CHEMBL394691 | — | — | 1 | 9.20 |
| CHEMBL246498 | — | — | 1 | 9.20 |
| CHEMBL398036 | — | — | 1 | 9.10 |
| CHEMBL246917 | — | — | 1 | 8.90 |
| CHEMBL246078 | — | — | 1 | 8.90 |
| CHEMBL246500 | — | — | 1 | 8.70 |
| CHEMBL246079 | — | — | 1 | 8.70 |
| CHEMBL394689 | — | — | 1 | 8.60 |
| CHEMBL398035 | — | — | 1 | 8.50 |
| CHEMBL247121 | — | — | 1 | 8.40 |
| CHEMBL394949 | — | — | 1 | 8.40 |
| CHEMBL438675 | — | — | 1 | 8.30 |
| CHEMBL246916 | — | — | 1 | 8.10 |
| CHEMBL246080 | — | — | 1 | 8.00 |
| CHEMBL246077 | — | — | 1 | 7.90 |
| CHEMBL247120 | — | — | 1 | 7.40 |
| CHEMBL247325 | — | — | 1 | 6.90 |
| CHEMBL246289 | — | — | 1 | 6.70 |
| CHEMBL246290 | — | — | 1 | 6.50 |
| CHEMBL247119 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398034 | — | Ki | = | 0.0631 | nM | 10.20 |
| CHEMBL394690 | — | Ki | = | 0.1585 | nM | 9.80 |
| CHEMBL246918 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL246706 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL246705 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL246499 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL246291 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL246704 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL394691 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL246498 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL398036 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL246917 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL246078 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL246500 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL246079 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL394689 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL398035 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL247121 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL394949 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL438675 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL246916 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL246080 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL246077 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL247120 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL247325 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL246289 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL246290 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL247119 | — | Ki | = | 630.96 | nM | 6.20 |