Assay Detail
Binding
CHEMBL886476
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Activity at RXR-LXR heterodimer in human THP1 cells assessed as induction of ABCA1 mRNA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.11 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL246821 | — | — | 1 | 8.44 |
| CHEMBL428930 | — | — | 1 | 8.00 |
| CHEMBL247856 | — | — | 1 | 7.40 |
| CHEMBL247819 | — | — | 1 | 7.36 |
| CHEMBL248191 | — | — | 1 | 6.79 |
| CHEMBL248415 | — | — | 1 | 6.75 |
| CHEMBL247836 | — | — | 1 | 6.70 |
| CHEMBL400557 | — | — | 1 | 6.53 |
| CHEMBL246805 | — | — | 1 | 6.01 |
| CHEMBL400380 | — | — | 1 | - |
| CHEMBL246806 | — | — | 1 | - |
| CHEMBL399765 | — | — | 1 | - |
| CHEMBL246629 | — | — | 1 | - |
| CHEMBL247005 | — | — | 1 | - |
| CHEMBL247855 | — | — | 1 | - |
| CHEMBL400490 | — | — | 1 | - |
| CHEMBL247857 | — | — | 1 | - |
| CHEMBL247011 | — | — | 1 | - |
| CHEMBL247012 | — | — | 1 | - |
| CHEMBL246625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL246821 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL428930 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL247856 | — | EC50 | = | 39.7 | nM | 7.40 |
| CHEMBL247819 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL248191 | — | EC50 | = | 163.0 | nM | 6.79 |
| CHEMBL248415 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL247836 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL400557 | — | EC50 | = | 296.0 | nM | 6.53 |
| CHEMBL246805 | — | EC50 | = | 975.0 | nM | 6.01 |
| CHEMBL400380 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL246806 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL399765 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL246629 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL247005 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL247855 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL400490 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL247857 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL247011 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL247012 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL246625 | — | EC50 | > | 3000.0 | nM | - |