Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL886478

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Activity at RXRalpha by GAL4DNA cotransfection assay
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Retinoic acid receptor RXR-alpha (CHEMBL2061)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia.
Lagu B, Pio B, Lebedev R, Yang M, Pelton PD.
Bioorg Med Chem Lett (2007) 17 : 3497 -3503
PubMed 17485209 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 7.56 9.05
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL248415 1 9.05
CHEMBL246821 1 8.74
CHEMBL247005 1 8.74
CHEMBL246629 1 8.68
CHEMBL428930 1 7.79
CHEMBL247819 1 7.74
CHEMBL247836 1 7.61
CHEMBL248191 1 7.21
CHEMBL400557 1 7.17
CHEMBL247012 1 7.01
CHEMBL247856 1 6.76
CHEMBL400380 1 5.92
CHEMBL247011 1 5.80
CHEMBL247855 1 -
CHEMBL246805 1 -
CHEMBL399765 1 -
CHEMBL247857 1 -
CHEMBL400490 1 -
CHEMBL246625 1 -
CHEMBL246806 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL248415 EC50 = 0.9 nM 9.05
CHEMBL246821 EC50 = 1.8 nM 8.74
CHEMBL247005 EC50 = 1.8 nM 8.74
CHEMBL246629 EC50 = 2.1 nM 8.68
CHEMBL428930 EC50 = 16.3 nM 7.79
CHEMBL247819 EC50 = 18.3 nM 7.74
CHEMBL247836 EC50 = 24.3 nM 7.61
CHEMBL248191 EC50 = 61.2 nM 7.21
CHEMBL400557 EC50 = 67.3 nM 7.17
CHEMBL247012 EC50 = 96.6 nM 7.01
CHEMBL247856 EC50 = 173.1 nM 6.76
CHEMBL400380 EC50 = 1200.0 nM 5.92
CHEMBL247011 EC50 = 1600.0 nM 5.80
CHEMBL247855 EC50 - -
CHEMBL246805 EC50 - -
CHEMBL399765 Activity - -
CHEMBL247857 EC50 - -
CHEMBL400490 EC50 - -
CHEMBL246625 EC50 - -
CHEMBL246806 EC50 > 10000.0 nM -