Assay Detail
Binding
CHEMBL886502
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Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane
41
Total Activities
41
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 8.02 | 9.52 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392798 | — | — | 1 | 9.52 |
| CHEMBL240005 | — | — | 1 | 9.10 |
| CHEMBL239824 | — | — | 1 | 9.05 |
| CHEMBL391082 | — | — | 1 | 8.96 |
| CHEMBL284414 | — | — | 1 | 8.92 |
| CHEMBL239822 | — | — | 1 | 8.89 |
| CHEMBL393807 | — | — | 1 | 8.85 |
| CHEMBL27460 | — | — | 1 | 8.85 |
| CHEMBL428033 | — | — | 1 | 8.82 |
| CHEMBL241086 | — | — | 1 | 8.70 |
| CHEMBL240215 | — | — | 1 | 8.64 |
| CHEMBL241112 | — | — | 1 | 8.62 |
| CHEMBL393781 | — | — | 1 | 8.59 |
| CHEMBL401451 | — | — | 1 | 8.49 |
| CHEMBL392893 | — | — | 1 | 8.46 |
| CHEMBL391083 | — | — | 1 | 8.34 |
| CHEMBL239820 | — | — | 1 | 8.20 |
| CHEMBL241272 | — | — | 1 | 8.17 |
| CHEMBL241087 | — | — | 1 | 8.08 |
| CHEMBL439212 | — | — | 1 | 8.05 |
| CHEMBL428563 | — | — | 1 | 8.05 |
| CHEMBL241085 | — | — | 1 | 7.97 |
| CHEMBL392969 | — | — | 1 | 7.97 |
| CHEMBL203356 | — | — | 1 | 7.96 |
| CHEMBL241079 | — | — | 1 | 7.94 |
| CHEMBL240033 | — | — | 1 | 7.85 |
| CHEMBL442090 | — | — | 1 | 7.84 |
| CHEMBL393980 | — | — | 1 | 7.82 |
| CHEMBL240216 | — | — | 1 | 7.77 |
| CHEMBL240657 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392798 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL240005 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL239824 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL391082 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL284414 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL239822 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL393807 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL27460 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL428033 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL241086 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL240215 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL241112 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL393781 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL401451 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL392893 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL391083 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL239820 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL241272 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL241087 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL428563 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL439212 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL241085 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL392969 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL203356 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL241079 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL240033 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL442090 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL393980 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL240216 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL240657 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL241067 | — | Ki | = | 36.5 | nM | 7.44 |
| CHEMBL391703 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL240001 | — | Ki | = | 61.2 | nM | 7.21 |
| CHEMBL240895 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL240896 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL241080 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL240870 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL239819 | — | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL239821 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL240897 | — | Ki | = | 824.0 | nM | 6.08 |
| CHEMBL240869 | — | Activity | - | — | - |