Assay Detail
Binding
CHEMBL886503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 5.32 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401451 | — | — | 1 | 6.14 |
| CHEMBL428033 | — | — | 1 | 6.13 |
| CHEMBL392893 | — | — | 1 | 5.99 |
| CHEMBL392798 | — | — | 1 | 5.91 |
| CHEMBL393807 | — | — | 1 | 5.89 |
| CHEMBL393781 | — | — | 1 | 5.86 |
| CHEMBL391082 | — | — | 1 | 5.85 |
| CHEMBL240215 | — | — | 1 | 5.79 |
| CHEMBL239822 | — | — | 1 | 5.75 |
| CHEMBL284414 | — | — | 1 | 5.73 |
| CHEMBL442090 | — | — | 1 | 5.72 |
| CHEMBL241086 | — | — | 1 | 5.64 |
| CHEMBL240005 | — | — | 1 | 5.62 |
| CHEMBL241087 | — | — | 1 | 5.61 |
| CHEMBL241085 | — | — | 1 | 5.60 |
| CHEMBL239824 | — | — | 1 | 5.58 |
| CHEMBL203356 | — | — | 1 | 5.53 |
| CHEMBL241112 | — | — | 1 | 5.47 |
| CHEMBL27460 | — | — | 1 | 5.46 |
| CHEMBL240896 | — | — | 1 | 5.42 |
| CHEMBL391083 | — | — | 1 | 5.33 |
| CHEMBL391703 | — | — | 1 | 5.25 |
| CHEMBL241079 | — | — | 1 | 5.22 |
| CHEMBL240216 | — | — | 1 | 5.17 |
| CHEMBL439212 | — | — | 1 | 5.07 |
| CHEMBL240033 | — | — | 1 | 5.05 |
| CHEMBL240870 | — | — | 1 | 5.01 |
| CHEMBL239821 | — | — | 1 | 4.99 |
| CHEMBL241067 | — | — | 1 | 4.94 |
| CHEMBL393980 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401451 | — | Ki | = | 724.5 | nM | 6.14 |
| CHEMBL428033 | — | Ki | = | 736.0 | nM | 6.13 |
| CHEMBL392893 | — | Ki | = | 1035.0 | nM | 5.99 |
| CHEMBL392798 | — | Ki | = | 1231.0 | nM | 5.91 |
| CHEMBL393807 | — | Ki | = | 1291.0 | nM | 5.89 |
| CHEMBL393781 | — | Ki | = | 1375.0 | nM | 5.86 |
| CHEMBL391082 | — | Ki | = | 1421.0 | nM | 5.85 |
| CHEMBL240215 | — | Ki | = | 1633.0 | nM | 5.79 |
| CHEMBL239822 | — | Ki | = | 1790.0 | nM | 5.75 |
| CHEMBL284414 | — | Ki | = | 1854.0 | nM | 5.73 |
| CHEMBL442090 | — | Ki | = | 1906.0 | nM | 5.72 |
| CHEMBL241086 | — | Ki | = | 2266.0 | nM | 5.64 |
| CHEMBL240005 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL241087 | — | Ki | = | 2461.0 | nM | 5.61 |
| CHEMBL241085 | — | Ki | = | 2511.0 | nM | 5.60 |
| CHEMBL239824 | — | Ki | = | 2650.0 | nM | 5.58 |
| CHEMBL203356 | — | Ki | = | 2946.0 | nM | 5.53 |
| CHEMBL241112 | — | Ki | = | 3373.0 | nM | 5.47 |
| CHEMBL27460 | — | Ki | = | 3511.0 | nM | 5.46 |
| CHEMBL240896 | — | Ki | = | 3791.0 | nM | 5.42 |
| CHEMBL391083 | — | Ki | = | 4680.0 | nM | 5.33 |
| CHEMBL391703 | — | Ki | = | 5598.0 | nM | 5.25 |
| CHEMBL241079 | — | Ki | = | 6042.0 | nM | 5.22 |
| CHEMBL240216 | — | Ki | = | 6846.0 | nM | 5.17 |
| CHEMBL439212 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL240033 | — | Ki | = | 8999.0 | nM | 5.05 |
| CHEMBL240870 | — | Ki | = | 9784.0 | nM | 5.01 |
| CHEMBL239821 | — | Ki | = | 10360.0 | nM | 4.99 |
| CHEMBL241067 | — | Ki | = | 11510.0 | nM | 4.94 |
| CHEMBL393980 | — | Ki | = | 11655.0 | nM | 4.93 |
| CHEMBL428563 | — | Ki | = | 14770.0 | nM | 4.83 |
| CHEMBL392969 | — | Ki | = | 15715.0 | nM | 4.80 |
| CHEMBL239820 | — | Ki | = | 16035.0 | nM | 4.79 |
| CHEMBL241080 | — | Ki | = | 24805.0 | nM | 4.61 |
| CHEMBL239819 | — | Ki | = | 26515.0 | nM | 4.58 |
| CHEMBL240895 | — | Ki | = | 31935.0 | nM | 4.50 |
| CHEMBL240657 | — | Ki | = | 37890.0 | nM | 4.42 |
| CHEMBL240001 | — | Ki | = | 73655.0 | nM | 4.13 |
| CHEMBL240869 | — | Ki | - | — | - | |
| CHEMBL241272 | — | Ki | = | 150385.0 | nM | - |
| CHEMBL240897 | — | Ki | - | — | - |