Assay Detail
Binding
CHEMBL886504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 6.68 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391082 | — | — | 1 | 7.89 |
| CHEMBL240005 | — | — | 1 | 7.86 |
| CHEMBL401451 | — | — | 1 | 7.79 |
| CHEMBL241112 | — | — | 1 | 7.65 |
| CHEMBL428033 | — | — | 1 | 7.59 |
| CHEMBL391083 | — | — | 1 | 7.58 |
| CHEMBL240033 | — | — | 1 | 7.58 |
| CHEMBL284414 | — | — | 1 | 7.50 |
| CHEMBL239824 | — | — | 1 | 7.47 |
| CHEMBL392893 | — | — | 1 | 7.30 |
| CHEMBL240215 | — | — | 1 | 7.28 |
| CHEMBL240216 | — | — | 1 | 7.22 |
| CHEMBL27460 | — | — | 1 | 7.19 |
| CHEMBL241085 | — | — | 1 | 7.18 |
| CHEMBL241086 | — | — | 1 | 7.03 |
| CHEMBL240657 | — | — | 1 | 6.86 |
| CHEMBL393781 | — | — | 1 | 6.84 |
| CHEMBL392798 | — | — | 1 | 6.84 |
| CHEMBL241087 | — | — | 1 | 6.77 |
| CHEMBL203356 | — | — | 1 | 6.71 |
| CHEMBL442090 | — | — | 1 | 6.69 |
| CHEMBL240896 | — | — | 1 | 6.60 |
| CHEMBL393807 | — | — | 1 | 6.55 |
| CHEMBL240895 | — | — | 1 | 6.49 |
| CHEMBL240001 | — | — | 1 | 6.29 |
| CHEMBL239822 | — | — | 1 | 6.27 |
| CHEMBL241079 | — | — | 1 | 6.24 |
| CHEMBL241067 | — | — | 1 | 6.11 |
| CHEMBL239820 | — | — | 1 | 6.07 |
| CHEMBL393980 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391082 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL240005 | — | Ki | = | 13.7 | nM | 7.86 |
| CHEMBL401451 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL241112 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL428033 | — | Ki | = | 25.5 | nM | 7.59 |
| CHEMBL391083 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL240033 | — | Ki | = | 26.2 | nM | 7.58 |
| CHEMBL284414 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL239824 | — | Ki | = | 33.5 | nM | 7.47 |
| CHEMBL392893 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL240215 | — | Ki | = | 52.3 | nM | 7.28 |
| CHEMBL240216 | — | Ki | = | 60.5 | nM | 7.22 |
| CHEMBL27460 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL241085 | — | Ki | = | 66.5 | nM | 7.18 |
| CHEMBL241086 | — | Ki | = | 94.5 | nM | 7.03 |
| CHEMBL240657 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL393781 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL392798 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL241087 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL203356 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL442090 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL240896 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL393807 | — | Ki | = | 282.0 | nM | 6.55 |
| CHEMBL240895 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL240001 | — | Ki | = | 517.0 | nM | 6.29 |
| CHEMBL239822 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL241079 | — | Ki | = | 579.0 | nM | 6.24 |
| CHEMBL241067 | — | Ki | = | 776.0 | nM | 6.11 |
| CHEMBL239820 | — | Ki | = | 858.0 | nM | 6.07 |
| CHEMBL393980 | — | Ki | = | 938.0 | nM | 6.03 |
| CHEMBL428563 | — | Ki | = | 1086.0 | nM | 5.96 |
| CHEMBL392969 | — | Ki | = | 1183.0 | nM | 5.93 |
| CHEMBL239821 | — | Ki | = | 1448.0 | nM | 5.84 |
| CHEMBL439212 | — | Ki | = | 1602.0 | nM | 5.79 |
| CHEMBL240870 | — | Ki | = | 1672.0 | nM | 5.78 |
| CHEMBL391703 | — | Ki | = | 2009.0 | nM | 5.70 |
| CHEMBL241080 | — | Ki | = | 3529.0 | nM | 5.45 |
| CHEMBL239819 | — | Ki | = | 4628.0 | nM | 5.33 |
| CHEMBL241272 | — | Ki | = | 5887.0 | nM | 5.23 |
| CHEMBL240869 | — | Ki | - | — | - | |
| CHEMBL240897 | — | Ki | - | — | - |