Assay Detail
ADMET
CHEMBL886675
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Cytotoxicity against C8166 cells assessed as reduction in total cell number
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.58 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247522 | — | — | 1 | 5.47 |
| CHEMBL437756 | — | — | 1 | 4.17 |
| CHEMBL394946 | — | — | 1 | 4.10 |
| CHEMBL245888 | — | — | 1 | - |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
| CHEMBL443313 | — | — | 1 | - |
| CHEMBL247735 | — | — | 1 | - |
| CHEMBL247523 | — | — | 1 | - |
| CHEMBL394945 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247522 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL437756 | — | IC50 | = | 68150.0 | nM | 4.17 |
| CHEMBL394946 | — | IC50 | = | 79140.0 | nM | 4.10 |
| CHEMBL245888 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL61 | PODOFILOX | IC50 | < | 150.0 | nM | - |
| CHEMBL443313 | — | IC50 | > | 436680.0 | nM | - |
| CHEMBL247735 | — | IC50 | = | 137550.0 | nM | - |
| CHEMBL247523 | — | IC50 | > | 294550.0 | nM | - |
| CHEMBL394945 | — | IC50 | = | 103790.0 | nM | - |