Assay Detail
Functional
CHEMBL886743
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Antiviral activity against HCV 1b replicon in human 2209-23 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | 2209-23 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.68 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374528 | — | — | 1 | 6.24 |
| CHEMBL438605 | — | — | 1 | 5.91 |
| CHEMBL393857 | 4'-AZIDOCYTIDINE | -1.0 | 1 | 5.89 |
| CHEMBL396350 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374528 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL438605 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL393857 | 4'-AZIDOCYTIDINE | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL396350 | — | IC50 | = | 22000.0 | nM | 4.66 |