Assay Detail
Binding
CHEMBL886746
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Inhibition of HCV 1b BK NS5B570 RNA polymerase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.21 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393857 | 4'-AZIDOCYTIDINE | -1.0 | 1 | 6.54 |
| CHEMBL239183 | — | — | 1 | 6.52 |
| CHEMBL99478 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393857 | 4'-AZIDOCYTIDINE | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL239183 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL99478 | — | IC50 | = | 2700.0 | nM | 5.57 |