Assay Detail
Binding
CHEMBL886882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC8 by [3H]acetyl histone peptide assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.27 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156887 | — | — | 1 | 6.52 |
| CHEMBL245548 | — | — | 1 | 6.16 |
| CHEMBL245741 | — | — | 1 | 5.18 |
| CHEMBL115468 | — | — | 1 | 4.85 |
| CHEMBL154517 | — | — | 1 | 4.70 |
| CHEMBL396097 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156887 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL245548 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL245741 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL115468 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL154517 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL396097 | — | IC50 | = | 66000.0 | nM | 4.18 |