Assay Detail
Binding
CHEMBL887070
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Displacement of [3H]diprenorphine from human cloned kappa opioid receptor
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Further studies of tyrosine surrogates in opioid receptor peptide ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.10 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247368 | — | — | 1 | 6.68 |
| CHEMBL246956 | — | — | 1 | 6.34 |
| CHEMBL391580 | — | — | 1 | 5.99 |
| CHEMBL246739 | — | — | 1 | 5.89 |
| CHEMBL247758 | — | — | 1 | 5.62 |
| CHEMBL246572 | — | — | 1 | - |
| CHEMBL246479 | — | — | 1 | - |
| CHEMBL247760 | — | — | 1 | - |
| CHEMBL393867 | — | — | 1 | - |
| CHEMBL246740 | — | — | 1 | - |
| CHEMBL247759 | — | — | 1 | - |
| CHEMBL392275 | — | — | 1 | - |
| CHEMBL395863 | — | — | 1 | - |
| CHEMBL13786 | — | — | 1 | - |
| CHEMBL246682 | — | — | 1 | - |
| CHEMBL247562 | — | — | 1 | - |
| CHEMBL247163 | — | — | 1 | - |
| CHEMBL247363 | — | — | 1 | - |
| CHEMBL2372104 | — | — | 1 | - |
| CHEMBL31421 | — | — | 1 | - |
| CHEMBL247064 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247368 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL246956 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL391580 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL246739 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL247758 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL246572 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL246479 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL247760 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL393867 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL246740 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL247759 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL392275 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL395863 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL13786 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL246682 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL247562 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL247163 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL247363 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2372104 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL31421 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL247064 | — | Ki | > | 10000.0 | nM | - |