Assay Detail
Binding
CHEMBL887178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 recombinant integrase strand transfer activity
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Newer tetracycline derivatives: synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.74 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396688 | — | — | 1 | 4.92 |
| CHEMBL241495 | — | — | 1 | 4.92 |
| CHEMBL396907 | — | — | 1 | 4.89 |
| CHEMBL392565 | — | — | 1 | 4.87 |
| CHEMBL239176 | — | — | 1 | 4.77 |
| CHEMBL239177 | — | — | 1 | 4.75 |
| CHEMBL1237046 | ROLITETRACYCLINE | 2.0 | 1 | 4.47 |
| CHEMBL396686 | — | — | 1 | 4.36 |
| CHEMBL1440 | TETRACYCLINE | 4.0 | 1 | - |
| CHEMBL396687 | — | — | 1 | - |
| CHEMBL561 | LOMEFLOXACIN | 4.0 | 1 | - |
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | - |
| CHEMBL239813 | — | — | 1 | - |
| CHEMBL392612 | — | — | 1 | - |
| CHEMBL392611 | — | — | 1 | - |
| CHEMBL241293 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396688 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL241495 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL396907 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL392565 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL239176 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL239177 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1237046 | ROLITETRACYCLINE | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL396686 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1440 | TETRACYCLINE | IC50 | = | 188000.0 | nM | - |
| CHEMBL396687 | — | IC50 | - | — | - | |
| CHEMBL561 | LOMEFLOXACIN | IC50 | - | — | - | |
| CHEMBL1434 | MINOCYCLINE | IC50 | - | — | - | |
| CHEMBL239813 | — | IC50 | - | — | - | |
| CHEMBL392612 | — | IC50 | - | — | - | |
| CHEMBL392611 | — | IC50 | - | — | - | |
| CHEMBL241293 | — | IC50 | - | — | - |