Assay Detail
Binding
CHEMBL887264
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Binding affinity to Integrin alpha-v-beta-5 receptor by ELISA assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.82 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190128 | — | — | 1 | 9.68 |
| CHEMBL190309 | — | — | 1 | 9.30 |
| CHEMBL372443 | — | — | 1 | 9.17 |
| CHEMBL228605 | — | — | 1 | 9.02 |
| CHEMBL228272 | — | — | 1 | 8.96 |
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 8.68 |
| CHEMBL389937 | — | — | 1 | 7.96 |
| CHEMBL375456 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190128 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL190309 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL372443 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL228605 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL228272 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL429876 | CILENGITIDE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL389937 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL375456 | — | IC50 | = | 15.0 | nM | 7.82 |