Assay Detail
Binding
CHEMBL887265
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Binding affinity to Integrin alpha-5-beta-5 receptor by ELISA assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.91 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 7.85 |
| CHEMBL190128 | — | — | 1 | 7.82 |
| CHEMBL190309 | — | — | 1 | 7.62 |
| CHEMBL372443 | — | — | 1 | 7.39 |
| CHEMBL228272 | — | — | 1 | 6.97 |
| CHEMBL228605 | — | — | 1 | 6.60 |
| CHEMBL375456 | — | — | 1 | 5.96 |
| CHEMBL389937 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL190128 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL190309 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL372443 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL228272 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL228605 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL375456 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL389937 | — | IC50 | = | 9400.0 | nM | 5.03 |