Assay Detail
Binding
CHEMBL887347
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Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.00 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228972 | — | — | 1 | 7.96 |
| CHEMBL61248 | — | — | 1 | 7.70 |
| CHEMBL229023 | — | — | 1 | 7.54 |
| CHEMBL229024 | — | — | 1 | 7.20 |
| CHEMBL387951 | — | — | 1 | 7.15 |
| CHEMBL388620 | — | — | 1 | 6.86 |
| CHEMBL229019 | — | — | 1 | 6.79 |
| CHEMBL375238 | — | — | 1 | 6.78 |
| CHEMBL229076 | — | — | 1 | 6.68 |
| CHEMBL229077 | — | — | 1 | 6.65 |
| CHEMBL229021 | — | — | 1 | 6.64 |
| CHEMBL229025 | — | — | 1 | 6.55 |
| CHEMBL387952 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228972 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL61248 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL229023 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL229024 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL387951 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL388620 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL229019 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL375238 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL229076 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL229077 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL229021 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL229025 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL387952 | — | Ki | = | 362.0 | nM | 6.44 |