Assay Detail
Binding
CHEMBL887389
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Displacement of [3H]U-69593 from human kappa opioid receptors expressed in CHO cell membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
High-affinity carbamate analogues of morphinan at opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 9.30 | 10.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | — | 1 | 10.47 |
| CHEMBL397035 | — | — | 1 | 10.34 |
| CHEMBL242048 | — | — | 1 | 10.29 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 10.10 |
| CHEMBL263096 | — | — | 1 | 9.85 |
| CHEMBL427862 | — | — | 1 | 9.85 |
| CHEMBL394624 | — | — | 1 | 9.52 |
| CHEMBL242046 | — | — | 1 | 9.09 |
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 8.64 |
| CHEMBL245049 | — | — | 1 | 8.48 |
| CHEMBL241824 | — | — | 1 | 8.47 |
| CHEMBL242047 | — | — | 1 | 8.37 |
| CHEMBL241823 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL397035 | — | Ki | = | 0.046 | nM | 10.34 |
| CHEMBL242048 | — | Ki | = | 0.051 | nM | 10.29 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 0.079 | nM | 10.10 |
| CHEMBL263096 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL427862 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL394624 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL242046 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL592 | LEVORPHANOL | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL245049 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL241824 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL242047 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL241823 | — | Ki | = | 36.0 | nM | 7.44 |