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Assay Detail

CHEMBL887465

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of GST-tagged human recombinant JSP1
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Dual specificity protein phosphatase 22 (CHEMBL3924)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors.
Zhang L, Qiu B, Xiong B, Li X, Li J, Wang X, Li J, Shen J.
Bioorg Med Chem Lett (2007) 17 : 2118 -2122
PubMed 17303416 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.34 5.65

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL230941 1 5.65
CHEMBL230472 1 5.63
CHEMBL230576 1 5.60
CHEMBL396800 1 5.55
CHEMBL230843 1 5.52
CHEMBL230471 1 5.26
CHEMBL425838 1 5.09
CHEMBL446453 1 5.08
CHEMBL230681 1 5.08
CHEMBL230842 1 4.92
CHEMBL230577 1 -
CHEMBL230206 1 -
CHEMBL389107 1 -
CHEMBL230207 1 -
CHEMBL230093 1 -
CHEMBL439875 1 -
CHEMBL230258 1 -
CHEMBL397726 1 -
CHEMBL230362 1 -
CHEMBL230363 1 -
CHEMBL230470 1 -
CHEMBL395085 1 -
CHEMBL395086 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL230941 IC50 = 2250.0 nM 5.65
CHEMBL230472 IC50 = 2350.0 nM 5.63
CHEMBL230576 IC50 = 2500.0 nM 5.60
CHEMBL396800 IC50 = 2790.0 nM 5.55
CHEMBL230843 IC50 = 3020.0 nM 5.52
CHEMBL230471 IC50 = 5550.0 nM 5.26
CHEMBL425838 IC50 = 8050.0 nM 5.09
CHEMBL446453 IC50 = 8390.0 nM 5.08
CHEMBL230681 IC50 = 8360.0 nM 5.08
CHEMBL230842 IC50 = 12010.0 nM 4.92
CHEMBL230577 IC50 > 40000.0 nM -
CHEMBL230206 IC50 > 40000.0 nM -
CHEMBL389107 IC50 > 40000.0 nM -
CHEMBL230207 IC50 > 40000.0 nM -
CHEMBL230093 IC50 > 40000.0 nM -
CHEMBL439875 IC50 > 40000.0 nM -
CHEMBL230258 IC50 > 40000.0 nM -
CHEMBL397726 IC50 > 40000.0 nM -
CHEMBL230362 IC50 > 40000.0 nM -
CHEMBL230363 IC50 > 100000.0 nM -
CHEMBL230470 IC50 > 100000.0 nM -
CHEMBL395085 IC50 > 40000.0 nM -
CHEMBL395086 IC50 > 40000.0 nM -