Assay Detail
Binding
CHEMBL887589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p110gamma
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.19 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538346 | — | — | 1 | 6.60 |
| CHEMBL541643 | — | — | 1 | 6.18 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538346 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL541643 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL98350 | LY-294002 | IC50 | = | 1600.0 | nM | 5.80 |