Assay Detail
Binding
CHEMBL887626
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Inhibition of pTACE
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.37 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148169 | — | — | 1 | 9.00 |
| CHEMBL228320 | — | — | 1 | 8.05 |
| CHEMBL229072 | — | — | 1 | 7.85 |
| CHEMBL229070 | — | — | 1 | 7.54 |
| CHEMBL228318 | — | — | 1 | 7.47 |
| CHEMBL388124 | — | — | 1 | 7.43 |
| CHEMBL389691 | — | — | 1 | 6.79 |
| CHEMBL228268 | — | — | 1 | 6.36 |
| CHEMBL228319 | — | — | 1 | 5.80 |
| CHEMBL228267 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148169 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL228320 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL229072 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL229070 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL228318 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL388124 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL389691 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL228268 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL228319 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL228267 | — | IC50 | > | 1000.0 | nM | - |