Assay Detail
Binding
CHEMBL887627
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Binding affinity to MMP2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.65 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148169 | — | — | 1 | 5.69 |
| CHEMBL228268 | — | — | 1 | 5.61 |
| CHEMBL228320 | — | — | 1 | - |
| CHEMBL228319 | — | — | 1 | - |
| CHEMBL228318 | — | — | 1 | - |
| CHEMBL389691 | — | — | 1 | - |
| CHEMBL228267 | — | — | 1 | - |
| CHEMBL229072 | — | — | 1 | - |
| CHEMBL388124 | — | — | 1 | - |
| CHEMBL229070 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148169 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL228268 | — | Ki | = | 2472.0 | nM | 5.61 |
| CHEMBL228320 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL228319 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL228318 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL389691 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL228267 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL229072 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL388124 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL229070 | — | Ki | > | 3333.0 | nM | - |