Assay Detail
Binding
CHEMBL888080
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Inhibition of HIV1 integrase strand transfer activity
82
Total Activities
81
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 82 | 4.49 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240506 | — | — | 1 | 6.22 |
| CHEMBL241597 | — | — | 1 | 6.00 |
| CHEMBL388276 | — | — | 1 | 5.70 |
| CHEMBL241397 | — | — | 1 | 5.40 |
| CHEMBL239057 | — | — | 1 | 5.40 |
| CHEMBL401049 | — | — | 1 | 4.96 |
| CHEMBL239485 | — | — | 1 | 4.92 |
| CHEMBL401050 | — | — | 1 | 4.92 |
| CHEMBL241359 | — | — | 1 | 4.89 |
| CHEMBL240547 | — | — | 1 | 4.80 |
| CHEMBL392160 | — | — | 1 | 4.77 |
| CHEMBL241804 | — | — | 1 | 4.75 |
| CHEMBL394650 | — | — | 1 | 4.75 |
| CHEMBL240752 | — | — | 1 | 4.70 |
| CHEMBL239696 | — | — | 1 | 4.70 |
| CHEMBL240543 | — | — | 1 | 4.60 |
| CHEMBL391411 | — | — | 1 | 4.58 |
| CHEMBL241598 | — | — | 1 | 4.55 |
| CHEMBL391519 | — | — | 1 | 4.54 |
| CHEMBL239482 | — | — | 1 | 4.52 |
| CHEMBL395448 | — | — | 1 | 4.52 |
| CHEMBL241606 | — | — | 1 | 4.50 |
| CHEMBL240329 | — | — | 1 | 4.48 |
| CHEMBL240334 | — | — | 1 | 4.44 |
| CHEMBL240513 | — | — | 1 | 4.43 |
| CHEMBL182653 | — | — | 1 | 4.41 |
| CHEMBL240299 | — | — | 1 | 4.37 |
| CHEMBL241596 | — | — | 1 | 4.34 |
| CHEMBL148472 | — | — | 1 | 4.33 |
| CHEMBL240330 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240506 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL241597 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL388276 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL241397 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL239057 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL401049 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL239485 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL401050 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL241359 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL240547 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL392160 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL241804 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL394650 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL240752 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL239696 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL240543 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL391411 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL241598 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL391519 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL239482 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL395448 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL241606 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL240329 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL240334 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL240513 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL182653 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL240299 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL241596 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL148472 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL240330 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL239274 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL241396 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL240546 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL394683 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL399006 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL239244 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL239056 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL239484 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL391423 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL239483 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL240331 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL241183 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL240542 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL240333 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL240511 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL240548 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL240544 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL239275 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL238632 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL238633 | — | IC50 | = | 92000.0 | nM | 4.04 |