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Assay Detail

CHEMBL888084

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human HDAC 1
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Histone deacetylase 1 (CHEMBL325)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Aminosuberoyl hydroxamic acids (ASHAs): a potent new class of HDAC inhibitors.
Belvedere S, Witter DJ, Yan J, Secrist JP, Richon V, Miller TA.
Bioorg Med Chem Lett (2007) 17 : 3969 -3971
PubMed 17507219 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.76 8.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL393060 1 8.89
CHEMBL246189 1 8.46
CHEMBL391569 1 8.40
CHEMBL246390 1 8.11
CHEMBL246587 1 8.03
CHEMBL269475 1 8.00
CHEMBL397856 1 7.96
CHEMBL246778 1 7.92
CHEMBL221955 1 7.84
CHEMBL246586 1 7.75
CHEMBL245986 1 7.38
CHEMBL246589 1 7.32
CHEMBL98 VORINOSTAT 4.0 1 7.32
CHEMBL394309 1 7.29
CHEMBL428577 1 7.27
CHEMBL246391 1 7.03
CHEMBL246392 1 6.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL393060 IC50 = 1.3 nM 8.89
CHEMBL246189 IC50 = 3.5 nM 8.46
CHEMBL391569 IC50 = 4.0 nM 8.40
CHEMBL246390 IC50 = 7.7 nM 8.11
CHEMBL246587 IC50 = 9.4 nM 8.03
CHEMBL269475 IC50 = 10.0 nM 8.00
CHEMBL397856 IC50 = 11.1 nM 7.96
CHEMBL246778 IC50 = 12.1 nM 7.92
CHEMBL221955 IC50 = 14.5 nM 7.84
CHEMBL246586 IC50 = 18.0 nM 7.75
CHEMBL245986 IC50 = 42.0 nM 7.38
CHEMBL246589 IC50 = 48.0 nM 7.32
CHEMBL98 VORINOSTAT IC50 = 48.0 nM 7.32
CHEMBL394309 IC50 = 51.3 nM 7.29
CHEMBL428577 IC50 = 54.0 nM 7.27
CHEMBL246391 IC50 = 93.0 nM 7.03
CHEMBL246392 IC50 = 120.0 nM 6.92