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Assay Detail

CHEMBL888114

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]SRIF14 from rat sst2 receptor from rat brain cortex membrane
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Somatostatin receptor type 2 (CHEMBL2978)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists.
Hurth K, Enz A, Floersheim P, Gentsch C, Hoyer D, Langenegger D, Neumann P, Pfäffli P, Sorg D, Swoboda R, Vassout A, Troxler T.
Bioorg Med Chem Lett (2007) 17 : 3988 -3991
PubMed 17512199 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 55 5.12 9.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL250304 1 9.13
CHEMBL251111 1 5.69
CHEMBL250724 1 5.68
CHEMBL250914 1 5.63
CHEMBL251110 1 5.62
CHEMBL250912 1 5.60
CHEMBL250922 1 5.46
CHEMBL250921 1 5.44
CHEMBL400099 1 5.37
CHEMBL250305 1 5.36
CHEMBL428583 1 5.31
CHEMBL250703 1 5.29
CHEMBL250522 1 5.28
CHEMBL400137 1 5.28
CHEMBL250723 1 5.28
CHEMBL440962 1 5.26
CHEMBL250521 1 5.26
CHEMBL248715 1 5.24
CHEMBL251300 1 5.21
CHEMBL251116 1 5.18
CHEMBL250498 1 5.17
CHEMBL250920 1 5.15
CHEMBL249930 1 5.13
CHEMBL251541 OBELIN 1 5.11
CHEMBL250705 1 5.06
CHEMBL250098 1 5.06
CHEMBL400386 1 5.04
CHEMBL398319 1 5.04
CHEMBL249932 1 5.00
CHEMBL251120 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL250304 Kd = 0.7413 nM 9.13
CHEMBL251111 Kd = 2041.74 nM 5.69
CHEMBL250724 Kd = 2089.3 nM 5.68
CHEMBL250914 Kd = 2344.23 nM 5.63
CHEMBL251110 Kd = 2398.83 nM 5.62
CHEMBL250912 Kd = 2511.89 nM 5.60
CHEMBL250922 Kd = 3467.37 nM 5.46
CHEMBL250921 Kd = 3630.78 nM 5.44
CHEMBL400099 Kd = 4265.8 nM 5.37
CHEMBL250305 Kd = 4365.16 nM 5.36
CHEMBL428583 Kd = 4897.79 nM 5.31
CHEMBL250703 Kd = 5128.61 nM 5.29
CHEMBL400137 Kd = 5248.07 nM 5.28
CHEMBL250723 Kd = 5248.07 nM 5.28
CHEMBL250522 Kd = 5248.07 nM 5.28
CHEMBL440962 Kd = 5495.41 nM 5.26
CHEMBL250521 Kd = 5495.41 nM 5.26
CHEMBL248715 Kd = 5754.4 nM 5.24
CHEMBL251300 Kd = 6165.95 nM 5.21
CHEMBL251116 Kd = 6606.93 nM 5.18
CHEMBL250498 Kd = 6760.83 nM 5.17
CHEMBL250920 Kd = 7079.46 nM 5.15
CHEMBL249930 Kd = 7413.1 nM 5.13
CHEMBL251541 OBELIN Kd = 7762.47 nM 5.11
CHEMBL250098 Kd = 8709.64 nM 5.06
CHEMBL250705 Kd = 8709.64 nM 5.06
CHEMBL400386 Kd = 9120.11 nM 5.04
CHEMBL398319 Kd = 9120.11 nM 5.04
CHEMBL249932 Kd = 10000.0 nM 5.00
CHEMBL251120 Kd = 10000.0 nM 5.00
CHEMBL251334 Kd = 10232.93 nM 4.99
CHEMBL440233 Kd = 10232.93 nM 4.99
CHEMBL250314 Kd = 10471.29 nM 4.98
CHEMBL398681 Kd = 10964.78 nM 4.96
CHEMBL440235 Kd = 10964.78 nM 4.96
CHEMBL398655 Kd = 11748.98 nM 4.93
CHEMBL400709 Kd = 13182.57 nM 4.88
CHEMBL398656 Kd = 14125.38 nM 4.85
CHEMBL250900 Kd = 14791.08 nM 4.83
CHEMBL249892 Kd = 16595.87 nM 4.78
CHEMBL400136 Kd = 16595.87 nM 4.78
CHEMBL250111 Kd = 17782.79 nM 4.75
CHEMBL251311 Kd = 18620.87 nM 4.73
CHEMBL249893 Kd = 19952.62 nM 4.70
CHEMBL250313 Kd = 19952.62 nM 4.70
CHEMBL251121 Kd = 20892.96 nM 4.68
CHEMBL249723 Kd = 21379.62 nM 4.67
CHEMBL250715 Kd = 22387.21 nM 4.65
CHEMBL250704 Kd = 24547.09 nM 4.61
CHEMBL5483015 ARSENIC TRIOXIDE Kd = 25118.86 nM 4.60