Assay Detail
Functional
CHEMBL888188
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Inhibition of 13,14-dihydro-15-ketoprostaglandin D2-stimulated human eosinophils shape change
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Eosinophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.62 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245700 | — | — | 1 | 7.28 |
| CHEMBL245908 | — | — | 1 | 7.03 |
| CHEMBL397650 | — | — | 1 | 6.76 |
| CHEMBL398126 | — | — | 1 | 6.61 |
| CHEMBL246311 | — | — | 1 | 6.35 |
| CHEMBL395134 | — | — | 1 | 6.35 |
| CHEMBL397842 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245700 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL245908 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL397650 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL398126 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL246311 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL395134 | — | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL397842 | — | IC50 | = | 1013.0 | nM | 5.99 |