Assay Detail
Binding
CHEMBL888214
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Inhibition of NF-kappaB-mediated gene transcription in HepG2 cells by luciferase reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.07 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250854 | TYLOPHORINIDINE | — | 1 | 8.00 |
| CHEMBL250474 | — | — | 1 | 7.96 |
| CHEMBL398325 | TYLOPHORININE | — | 1 | 7.92 |
| CHEMBL399965 | — | — | 1 | 6.50 |
| CHEMBL400888 | — | — | 1 | 6.49 |
| CHEMBL401479 | TYLOPHORIDICINE F | — | 1 | 6.43 |
| CHEMBL249029 | TYLOPHORIDICINE C | — | 1 | 6.22 |
| CHEMBL399317 | — | — | 1 | - |
| CHEMBL53004 | TYLOPHORIDICINE E | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250854 | TYLOPHORINIDINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL250474 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL398325 | TYLOPHORININE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL399965 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL400888 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL401479 | TYLOPHORIDICINE F | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL249029 | TYLOPHORIDICINE C | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL399317 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL53004 | TYLOPHORIDICINE E | IC50 | > | 1000.0 | nM | - |