Assay Detail
Binding
CHEMBL888221
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MMP14
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.53 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250905 | — | — | 1 | 5.99 |
| CHEMBL250709 | — | — | 1 | 5.90 |
| CHEMBL250299 | — | — | 1 | 5.84 |
| CHEMBL250710 | — | — | 1 | 5.78 |
| CHEMBL250502 | — | — | 1 | 5.73 |
| CHEMBL250503 | — | — | 1 | 5.52 |
| CHEMBL250504 | — | — | 1 | 5.48 |
| CHEMBL399096 | — | — | 1 | 5.47 |
| CHEMBL250093 | — | — | 1 | 5.46 |
| CHEMBL250297 | — | — | 1 | 5.38 |
| CHEMBL250708 | — | — | 1 | 5.25 |
| CHEMBL399097 | — | — | 1 | 5.25 |
| CHEMBL250298 | — | — | 1 | 5.25 |
| CHEMBL250094 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250905 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL250709 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL250299 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL250710 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL250502 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL250503 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL250504 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL399096 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL250093 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL250297 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL250708 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL399097 | — | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL250298 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL250094 | — | IC50 | = | 7440.0 | nM | 5.13 |