Assay Detail
Functional
CHEMBL888222
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Inhibition of LPS-stimulated TNFalpha production in RAW cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.13 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250504 | — | — | 1 | 6.52 |
| CHEMBL250094 | — | — | 1 | 6.12 |
| CHEMBL250093 | — | — | 1 | 6.06 |
| CHEMBL399096 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250504 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL250094 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL250093 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL399096 | — | IC50 | = | 1550.0 | nM | 5.81 |