Assay Detail
Binding
CHEMBL888231
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Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL3710) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.13 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 9.48 |
| CHEMBL251294 | — | — | 1 | 5.05 |
| CHEMBL251505 | — | — | 1 | 5.00 |
| CHEMBL251504 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL251294 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL251505 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL251504 | — | Ki | = | 10000.0 | nM | 5.00 |