Assay Detail
Binding
CHEMBL888275
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Inhibition of CDK1
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.55 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248713 | — | — | 1 | 9.15 |
| CHEMBL429478 | — | — | 1 | 9.10 |
| CHEMBL248712 | — | — | 1 | 8.96 |
| CHEMBL249303 | — | — | 1 | 8.74 |
| CHEMBL400749 | — | — | 1 | 8.60 |
| CHEMBL400569 | — | — | 1 | 8.52 |
| CHEMBL248891 | — | — | 1 | 8.25 |
| CHEMBL400568 | — | — | 1 | 8.13 |
| CHEMBL249500 | — | — | 1 | 8.07 |
| CHEMBL400906 | — | — | 1 | 8.05 |
| CHEMBL401064 | — | — | 1 | 7.89 |
| CHEMBL249304 | — | — | 1 | 7.85 |
| CHEMBL391437 | — | — | 1 | 7.64 |
| CHEMBL400859 | — | — | 1 | 7.54 |
| CHEMBL249502 | — | — | 1 | 7.41 |
| CHEMBL248890 | — | — | 1 | 7.39 |
| CHEMBL251739 | — | — | 1 | 7.28 |
| CHEMBL400858 | — | — | 1 | 7.01 |
| CHEMBL249094 | — | — | 1 | 7.00 |
| CHEMBL249519 | — | — | 1 | 6.96 |
| CHEMBL251740 | — | — | 1 | 6.92 |
| CHEMBL249518 | — | — | 1 | 6.92 |
| CHEMBL249501 | — | — | 1 | 6.27 |
| CHEMBL249302 | — | — | 1 | 5.89 |
| CHEMBL249095 | — | — | 1 | 5.87 |
| CHEMBL399042 | — | — | 1 | 5.00 |
| CHEMBL249096 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248713 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL429478 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL248712 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL249303 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL400749 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL400569 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL248891 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL400568 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL249500 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL400906 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL401064 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL249304 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL391437 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL400859 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL249502 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL248890 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL251739 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL400858 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL249094 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL249519 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL251740 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL249518 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL249501 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL249302 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL249095 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL399042 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL249096 | — | IC50 | > | 1000.0 | nM | - |