Assay Detail
Binding
CHEMBL888279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RET
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Proto-oncogene tyrosine-protein kinase receptor Ret (CHEMBL2041) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.16 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248713 | — | — | 1 | 6.96 |
| CHEMBL400569 | — | — | 1 | 6.85 |
| CHEMBL248712 | — | — | 1 | 6.41 |
| CHEMBL249502 | — | — | 1 | 6.39 |
| CHEMBL249303 | — | — | 1 | 6.00 |
| CHEMBL249304 | — | — | 1 | 6.00 |
| CHEMBL249500 | — | — | 1 | 6.00 |
| CHEMBL400749 | — | — | 1 | 6.00 |
| CHEMBL429478 | — | — | 1 | 6.00 |
| CHEMBL400859 | — | — | 1 | 5.96 |
| CHEMBL251739 | — | — | 1 | 5.91 |
| CHEMBL249518 | — | — | 1 | 5.49 |
| CHEMBL400906 | — | — | 1 | - |
| CHEMBL400568 | — | — | 1 | - |
| CHEMBL251740 | — | — | 1 | - |
| CHEMBL249501 | — | — | 1 | - |
| CHEMBL399042 | — | — | 1 | - |
| CHEMBL401064 | — | — | 1 | - |
| CHEMBL249302 | — | — | 1 | - |
| CHEMBL249096 | — | — | 1 | - |
| CHEMBL249095 | — | — | 1 | - |
| CHEMBL249094 | — | — | 1 | - |
| CHEMBL248891 | — | — | 1 | - |
| CHEMBL248890 | — | — | 1 | - |
| CHEMBL391437 | — | — | 1 | - |
| CHEMBL400858 | — | — | 1 | - |
| CHEMBL249519 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248713 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL400569 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL248712 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL249502 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL249303 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL249304 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL249500 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL400749 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL429478 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL400859 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL251739 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL249518 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL400906 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL400568 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL251740 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL249501 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL399042 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL401064 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL249302 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL249096 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL249095 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL249094 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL248891 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL248890 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL391437 | — | IC50 | - | — | - | |
| CHEMBL400858 | — | IC50 | - | — | - | |
| CHEMBL249519 | — | IC50 | > | 10000.0 | nM | - |