Assay Detail
Functional
CHEMBL888332
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Inhibition of LPS-induced TNFalpha production in PBMC
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.70 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399486 | — | — | 1 | 7.19 |
| CHEMBL400078 | — | — | 1 | 7.17 |
| CHEMBL249280 | — | — | 1 | 7.02 |
| CHEMBL251724 | — | — | 1 | 6.85 |
| CHEMBL249697 | BMS-345541 | — | 1 | 6.10 |
| CHEMBL398253 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399486 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL400078 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL249280 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL251724 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL249697 | BMS-345541 | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL398253 | — | EC50 | = | 1370.0 | nM | 5.86 |