Assay Detail
Functional
CHEMBL888358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of doxorubicin-induced cell cycle arrest in H1299 cells by accumulation at G2/M phase by FACS analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.42 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245796 | — | — | 1 | 6.70 |
| CHEMBL248012 | — | — | 1 | 6.70 |
| CHEMBL248040 | — | — | 1 | 6.52 |
| CHEMBL248193 | — | — | 1 | 6.40 |
| CHEMBL247459 | — | — | 1 | 6.40 |
| CHEMBL248010 | — | — | 1 | 6.30 |
| CHEMBL248005 | — | — | 1 | 6.22 |
| CHEMBL248038 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245796 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL248012 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL248040 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL248193 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL247459 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL248010 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL248005 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL248038 | — | EC50 | = | 800.0 | nM | 6.10 |