Assay Detail
Binding
CHEMBL888453
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.79 | 7.77 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226578 | — | — | 1 | 7.77 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.77 |
| CHEMBL389660 | — | — | 1 | 6.47 |
| CHEMBL226678 | — | — | 1 | 6.14 |
| CHEMBL226679 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226578 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL389660 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL226678 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL226679 | — | Activity | - | — | - |