Assay Detail
Functional
CHEMBL888517
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Antagonist activity at human P2Y1 receptor expressed in 1321N1 cells assessed as inhibition of 2-MeS-ADP-induced inositol phosphate formation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.98 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390149 | — | — | 1 | 7.03 |
| CHEMBL153254 | — | — | 1 | 6.21 |
| CHEMBL227235 | — | — | 1 | 6.10 |
| CHEMBL226857 | — | — | 1 | 6.06 |
| CHEMBL375022 | — | — | 1 | 5.81 |
| CHEMBL226807 | — | — | 1 | 5.76 |
| CHEMBL435930 | — | — | 1 | 5.71 |
| CHEMBL375682 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390149 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL153254 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL227235 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL226857 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL375022 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL226807 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL435930 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL375682 | — | IC50 | = | 6900.0 | nM | 5.16 |