Assay Detail
Binding
CHEMBL888534
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Inhibition of HIV1 integrase expressed in Escherichia coli BL21 (DE3)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Rationally designed dual inhibitors of HIV reverse transcriptase and integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.94 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242883 | — | — | 1 | 7.03 |
| CHEMBL178865 | — | — | 1 | 6.52 |
| CHEMBL1161970 | — | — | 1 | 6.16 |
| CHEMBL390489 | — | — | 1 | 5.96 |
| CHEMBL265377 | — | — | 1 | 5.74 |
| CHEMBL388707 | — | — | 1 | 5.62 |
| CHEMBL244167 | — | — | 1 | 5.35 |
| CHEMBL243536 | — | — | 1 | 5.12 |
| CHEMBL436546 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242883 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL178865 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1161970 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL390489 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL265377 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL388707 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL244167 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL243536 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL436546 | — | IC50 | > | 100000.0 | nM | - |