Assay Detail
Functional
CHEMBL888633
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Cytotoxicity against human MCF7 cells after 48 hrs by SRB binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel antitumor antimitotic agents that also reverse tumor resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.42 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388289 | — | — | 1 | 6.52 |
| CHEMBL227262 | — | — | 1 | 5.64 |
| CHEMBL388290 | — | — | 1 | 5.10 |
| CHEMBL227263 | — | — | 1 | 4.97 |
| CHEMBL427429 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388289 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL227262 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL388290 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL227263 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL427429 | — | IC50 | = | 13000.0 | nM | 4.89 |