Assay Detail
Functional
CHEMBL888636
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Growth inhibition of Pgp deficient MCF7 cells expressing MRP1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel antitumor antimitotic agents that also reverse tumor resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.23 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 9.22 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.60 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.55 |
| CHEMBL388289 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL388289 | — | IC50 | = | 280.0 | nM | 6.55 |