Assay Detail
Functional
CHEMBL888663
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilization
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.13 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66654 | — | — | 1 | 8.82 |
| CHEMBL227200 | — | — | 1 | 8.64 |
| CHEMBL390802 | — | — | 1 | 8.38 |
| CHEMBL390803 | — | — | 1 | 8.22 |
| CHEMBL390805 | — | — | 1 | 7.28 |
| CHEMBL387873 | — | — | 1 | 7.10 |
| CHEMBL227202 | — | — | 1 | 7.07 |
| CHEMBL227201 | — | — | 1 | 7.02 |
| CHEMBL226832 | — | — | 1 | 6.88 |
| CHEMBL227199 | — | — | 1 | 6.85 |
| CHEMBL390804 | — | — | 1 | 6.51 |
| CHEMBL226831 | — | — | 1 | 6.29 |
| CHEMBL226833 | — | — | 1 | 5.72 |
| CHEMBL227157 | — | — | 1 | 5.05 |
| CHEMBL229707 | — | — | 1 | - |
| CHEMBL390494 | — | — | 1 | - |
| CHEMBL441719 | — | — | 1 | - |
| CHEMBL375680 | — | — | 1 | - |
| CHEMBL227156 | — | — | 1 | - |
| CHEMBL226834 | — | — | 1 | - |
| CHEMBL226621 | — | — | 1 | - |
| CHEMBL226830 | — | — | 1 | - |
| CHEMBL226783 | — | — | 1 | - |
| CHEMBL390801 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66654 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL227200 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL390802 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL390803 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL390805 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL387873 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL227202 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL227201 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL226832 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL227199 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL390804 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL226831 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL226833 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL227157 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL229707 | — | IC50 | - | — | - | |
| CHEMBL390494 | — | IC50 | - | — | - | |
| CHEMBL441719 | — | IC50 | - | — | - | |
| CHEMBL375680 | — | IC50 | - | — | - | |
| CHEMBL227156 | — | IC50 | - | — | - | |
| CHEMBL226834 | — | IC50 | - | — | - | |
| CHEMBL226621 | — | IC50 | - | — | - | |
| CHEMBL226830 | — | IC50 | - | — | - | |
| CHEMBL226783 | — | IC50 | - | — | - | |
| CHEMBL390801 | — | IC50 | - | — | - |