Assay Detail
Binding
CHEMBL888891
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Inhibition of HMGCoA reductase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.23 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228955 | — | — | 1 | 9.52 |
| CHEMBL389002 | — | — | 1 | 8.74 |
| CHEMBL228528 | — | — | 1 | 8.72 |
| CHEMBL389216 | — | — | 1 | 8.54 |
| CHEMBL391002 | — | — | 1 | 8.52 |
| CHEMBL389442 | — | — | 1 | 8.52 |
| CHEMBL387514 | — | — | 1 | 8.46 |
| CHEMBL389443 | — | — | 1 | 8.33 |
| CHEMBL228667 | — | — | 1 | 8.02 |
| CHEMBL228954 | — | — | 1 | 7.93 |
| CHEMBL389441 | — | — | 1 | 7.86 |
| CHEMBL389217 | — | — | 1 | 7.79 |
| CHEMBL438662 | — | — | 1 | 7.78 |
| CHEMBL228583 | — | — | 1 | 7.43 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228955 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL389002 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL228528 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL389216 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL391002 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL389442 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL387514 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL389443 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL228667 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL228954 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL389441 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL389217 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL438662 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL228583 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 49.0 | nM | 7.31 |