Assay Detail
Binding
CHEMBL888903
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Displacement of [3H]DTG from sigma 2 receptor in rat liver membrane after 120 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.22 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227071 | — | — | 1 | 9.59 |
| CHEMBL226540 | — | — | 1 | 9.19 |
| CHEMBL387741 | — | — | 1 | 8.97 |
| CHEMBL226539 | — | — | 1 | 8.16 |
| CHEMBL389261 | — | — | 1 | 6.99 |
| CHEMBL226538 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227071 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL226540 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL387741 | — | Ki | = | 1.06 | nM | 8.97 |
| CHEMBL226539 | — | Ki | = | 6.95 | nM | 8.16 |
| CHEMBL389261 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL226538 | — | Ki | = | 386.0 | nM | 6.41 |