Assay Detail
Binding
CHEMBL889103
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Displacement of [125I]MCP1 from mouse CCR2 receptor expressed in CHO cells
26
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.36 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230932 | — | — | 1 | 8.46 |
| CHEMBL230933 | — | — | 1 | 8.30 |
| CHEMBL231039 | — | — | 1 | 8.12 |
| CHEMBL437359 | — | — | 1 | 8.10 |
| CHEMBL230721 | — | — | 1 | 7.82 |
| CHEMBL436796 | — | — | 1 | 7.82 |
| CHEMBL231246 | — | — | 1 | 7.77 |
| CHEMBL231038 | — | — | 1 | 7.77 |
| CHEMBL388007 | — | — | 1 | 7.76 |
| CHEMBL398000 | — | — | 1 | 7.58 |
| CHEMBL231142 | — | — | 3 | 7.55 |
| CHEMBL266017 | — | — | 1 | 7.35 |
| CHEMBL387587 | — | — | 1 | 7.35 |
| CHEMBL230722 | — | — | 1 | 7.24 |
| CHEMBL230078 | — | — | 1 | 7.20 |
| CHEMBL230405 | — | — | 1 | 7.19 |
| CHEMBL230832 | — | — | 1 | 7.18 |
| CHEMBL389610 | — | — | 1 | 7.13 |
| CHEMBL230831 | — | — | 1 | 7.03 |
| CHEMBL230617 | — | — | 1 | 6.90 |
| CHEMBL231143 | — | — | 1 | 6.89 |
| CHEMBL231247 | — | — | 1 | 6.71 |
| CHEMBL398001 | — | — | 1 | 6.55 |
| CHEMBL388675 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230932 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL230933 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL231039 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL437359 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL230721 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL436796 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL231246 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL231038 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL388007 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL398000 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL231142 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL387587 | — | IC50 | = | 44.3 | nM | 7.35 |
| CHEMBL266017 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL230722 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL230078 | — | IC50 | = | 63.5 | nM | 7.20 |
| CHEMBL230405 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL230832 | — | IC50 | = | 65.5 | nM | 7.18 |
| CHEMBL389610 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL230831 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL230617 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL231143 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL231142 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL231247 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL398001 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL388675 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL231142 | — | IC50 | = | 559.0 | nM | 6.25 |