Assay Detail
Binding
CHEMBL889104
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Displacement of [125I]MCP1 from human CCR2 I40L mutant expressed in CHO cells
28
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.89 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437359 | — | — | 1 | 8.72 |
| CHEMBL230933 | — | — | 1 | 8.51 |
| CHEMBL230932 | — | — | 1 | 8.48 |
| CHEMBL231246 | — | — | 1 | 8.46 |
| CHEMBL231039 | — | — | 1 | 8.41 |
| CHEMBL230722 | — | — | 1 | 8.40 |
| CHEMBL231038 | — | — | 1 | 8.30 |
| CHEMBL436796 | — | — | 1 | 8.26 |
| CHEMBL231142 | — | — | 4 | 8.20 |
| CHEMBL266017 | — | — | 1 | 8.19 |
| CHEMBL230721 | — | — | 1 | 8.12 |
| CHEMBL398000 | — | — | 1 | 8.10 |
| CHEMBL389610 | — | — | 1 | 8.07 |
| CHEMBL230617 | — | — | 1 | 8.05 |
| CHEMBL388007 | — | — | 1 | 8.00 |
| CHEMBL230832 | — | — | 1 | 7.89 |
| CHEMBL230831 | — | — | 1 | 7.81 |
| CHEMBL387587 | — | — | 1 | 7.80 |
| CHEMBL230405 | — | — | 1 | 7.72 |
| CHEMBL230078 | — | — | 1 | 7.70 |
| CHEMBL230616 | — | — | 1 | 7.70 |
| CHEMBL231143 | — | — | 1 | 7.57 |
| CHEMBL388675 | — | — | 1 | 7.55 |
| CHEMBL231247 | — | — | 1 | 7.17 |
| CHEMBL398001 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437359 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL230933 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL230932 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL231246 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL231039 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL230722 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL231038 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL436796 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL231142 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL266017 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL230721 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL398000 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL389610 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL230617 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL388007 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL230832 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL230831 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL387587 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL230405 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL230078 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL230616 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL231143 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL388675 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL231142 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL231247 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL231142 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL231142 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL398001 | — | IC50 | = | 231.0 | nM | 6.64 |